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Predictions and picks for Week 10 of the 2022 NFL season

Home » NFL » NFL Week 10 Predictions 2022: Picks & Previews for Week 10

The NFL season is officially half over, which means it’s time to make NFL Week 10 predictions. Just like last week, we don’t expect our NFL picks for today to be easy.

The week 9 schedule brought a few surprising results, and to make things even more challenging, nearly half of the games in Week 10 opened with a spread of three points or less.

NFL Week 10 predictions 2022

As always, we can’t make any guarantees with our NFL Week 10 predictions. That’s just the nature of the season thus far with few guarantees.

But our NFL picks for today are meant to be a guide. Whether you want NFL picks straight up or NFL picks against the spread, you’re in the right place. Let’s take a closer look at our NFL Week 10 picks.

Odds courtesy of FanDuel — Join FanDuel Sportsbook for up to $1000 in free bets.


Texans vs Giants

Even though the Giants suffered a road loss against the Seahawks in their last game, there’s no reason to doubt that the G-Men’s 6-2 start isn’t for real. The caveat is that all of their wins have been close games. Those six wins have come by an average of 4.5 points with only one win coming by more than six points. While they’ve been able to grind out wins, Daniel Jones doesn’t give them the kind of passing game the Giants need to pull away from bad teams and cover a spread this big.

Our NFL Week 10 predictions in 2022 also give the Texans the benefit of the doubt. Three of Houston’s six losses have come by seven points or less, as Lovie Smith has made the Texans respectable defensively.

Even if they don’t score a lot of points, they’ll have a plan for slowing down Saquon Barkley. Houston probably won’t win on the road, but the Texans won’t make it easy on the Giants.

  • SU Pick: Giants (-275)
  • ATS Pick: Texans +6.5 (-110)

Vikings vs Bills

Last week’s loss to the Jets proved that Buffalo’s offense isn’t invincible, even if Josh Allen is still at the top when it comes to NFL MVP odds. On the other hand, the Bills have won all of their home games by at least 10 points, which is a good indication that they’ll be able to bounce back this week.

But winning by double digits or covering a spread this big will be difficult against the 7-1 Vikings.


For what it’s worth, the Vikings lost their only game against a team with a winning record this year. But they will still be a tough out for the Bills with a balanced offense that averages over 24 points per game.

With playmakers like Dalvin Cook and Justin Jefferson, the Minnesota offense should be able to move the ball, making it tough for the Bills to get separation and cover the spread.

  • SU Pick: Bills (-270)
  • ATS Pick: Vikings +6.5 (-110)

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Browns vs Dolphins

When Tua Tagovailoa starts and finishes a game, the Dolphins are undefeated, so our NFL Week 10 picks aren’t going to go against Miami winning this game. However, the Dolphins haven’t covered the spread in six straight weeks and have only covered the spread once as a favorite this season.

Keep in mind they’ve allowed 59 total points against the Lions and Bears over the last two weeks, making the Miami defense tough to trust and increasing the chances this game is only decided by a field goal.

Of course, the Browns have the type of rushing attack behind Nick Chubb that can take advantage of a porous defense. In fairness, the Cleveland defense is also problematic, giving up close to 25 points per game. But since the Browns are averaging 25 points per game, they’ll be able to keep pace in a high-scoring game and at least beat the spread, even if they can’t pull off another win.

  • SU Pick: Dolphins (-205)
  • ATS Pick: Browns +4 (-110)

Cardinals vs Rams

The Rams are undoubtedly spiraling, losing four of their last five games. However, they have dominated the Cardinals in recent years, winning 11 of their last 12 head-to-head meetings with Arizona.

That includes a 20-12 win in the desert earlier this season. Despite everything that has gone wrong for the Rams this year, our NFL Week 10 predictions for 2022 can’t ignore the recent history between these teams, especially a win earlier this year.

On top of that, the Cardinals haven’t done much this year to make us believe in them either. They’ve also lost four of their last five games while also giving up at least 30 points in three straight games.

Arizona has now allowed the second-most points in the NFL this season. That’s exactly what Matthew Stafford and the Rams need to get going offensively and earn a much-needed win at home.

  • SU Pick: Rams (-164)
  • ATS Pick: Rams -3 (-112)

Chargers vs 49ers

It’s a little puzzling why the 49ers are such heavy favorites in this game. They’ve already lost two games to AFC West opponents this year and don’t exactly have a reliable offense with Jimmy Garoppolo running the show.

Even with a good supporting cast around him, Garoppolo is always a risk when it comes to ball security. Nevertheless, the 49ers have one of the best defenses in the league with Nick Bosa racking up 8.5 sacks in seven games, putting him near the top of the NFL DPOY odds.

But even if the defense is enough to win the game, the 49ers will have a hard time covering the spread. The Chargers have won their last three road games, albeit against subpar teams. They also have one of the best passing attacks in the league behind Justin Herbert. The San Francisco defense won’t be able to keep Herbert under wraps all game, enabling the Chargers to keep this game close, even if they can’t pull off the win.

  • SU Pick: 49ers (-300)
  • ATS Pick: Chargers +7 (-110)

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