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Predictions and picks for Week 13 of the 2022 NFL season

Home » NFL » NFL Week 13 Predictions 2022: Picks & Previews for Week 13

With December upon us, the NFL season is entering its stretch run as we get set to make our NFL Week 13 predictions in 2022.

As usual, there were multiple games that threw us for a loop last week and could give us second thoughts about our NFL picks for today. But we won’t let a little uncertainty keep us from making NFL picks straight up or even NFL picks against the spread.

NFL Week 13 predictions 2022

  • Jaguars vs Lions
  • Commanders vs Giants
  • Packers vs Bears
  • Chiefs vs Bengals
  • Saints vs Buccaneers

This week’s schedule includes six games between division rivals and six games between teams with a winning record, including a rematch of last year’s AFC Championship Game. Surely, that increases the challenge when making our NFL Week 13 predictions for 2022. But after closely examining all of this week’s games, we’re happy to share our NFL Week 13 picks.

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Jaguars vs Lions 

While the Jaguars are coming off a big win over the Ravens, the Lions have been trending in the right direction for several weeks. Our NFL picks for today reflect the fact that Dan Campbell has his team playing hard despite giving up the most points in the league.


The Lions won three straight games and then gave the Bills a lot of trouble on Thanksgiving. There’s no reason why that shouldn’t continue, especially with a few extra days of rest before this game.

Meanwhile, the Jaguars have been dreadful on the road this season, which is something we took into account with our NFL Week 13 predictions in 2022.

Jacksonville’s stunning win over the Chargers in Week 3 is the team’s only win away from home this season. They’re just 1-5 in road and neutral-site games this season, making them an unreliable team to pick, even in a toss-up game against the Lions.

  • SU Pick: Lions (-116)
  • ATS Pick: Lions -1.5 (-106)

Commanders vs Giants

With three losses in their last four games, the Giants are seeing their once-promising season unravel. They find themselves as home underdogs this week, which is actually a scenario that has suited them well this season.

They still have a bonafide star in Saquon Barkley and usually get just enough from their defense, which has been enough to win some close games at home. 


Keep in mind that the Commanders aren’t exactly world-beaters. Granted, Washington has won six of its last seven games. But a shocking upset of the Eagles is the only win over a team with a winning record during that stretch.

Taylor Heinicke has made the offense functional, although the Commanders have still scored less than 20 points in four of their last seven games. That’s not the type of team that makes us feel confident as a road favorite against a division rival. 

  • SU Pick: Giants (+108)
  • ATS Pick: Giants +1.5 (-106)

Packers vs Bears

As far as the Packers have fallen, they shouldn’t be losing to the Bears. They found some success on offense last week against the Eagles, scoring 33 points despite Jordan Love replacing Aaron Rodgers after he hurt his ribs.

The Bears have allowed at least 30 points in four of their last five games during their latest losing streak. That should allow the Green Bay offense to keep it going this week regardless of who’s at quarterback.

Of course, the Bears have problems of their own after a 31-10 loss to the Jets. Justin Fields was inactive last week due to a shoulder injury and now Darnell Mooney has been ruled out for the season.

Even when Fields was healthy, his efforts weren’t enough to overcome a defense that’s conceding 25.4 points per game. Even if the Packers have plenty of questions to answer themselves, our NFL Week 13 picks are going against the Bears more so than in Green Bay’s favor. With the spread in this game being negligible, the Packers should be able to win and cover.

  • SU Pick: Packers (-154)
  • ATS Pick: Packers -3 (-110)

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Chiefs vs Bengals

This seems like the perfect time for a rematch of last year’s AFC Championship Game. Cincinnati has won three in a row and five of the team’s last six games. Even without Ja’Marr Chase available, Joe Burrow’s NFL MVP odds seem to get better every week.

The Bengals are also poised for a strong finish with four of their last six games coming at home. Behind Burrow, the Bengals have averaged 34.7 points per game over their last three home games. The Cincinnati defense has also been better than people realize, so they won’t fear Patrick Mahomes and company.

Granted, Mahomes is still the MVP frontrunner. But the Chiefs continue to have plenty of flaws. They are average defensively and still don’t have a running game that consistently produces to take the pressure off Mahomes.

Against a team like the Bengals that can keep pace with them offensively, the Chiefs might have a hard time covering on the road, especially with four of their wins coming by three points or less. We’re taking a little bit of a chance here with our NFL Week 13 predictions in 2022, but we like the Bengals to spring the upset on Kansas City again.

  • SU Pick: Bengals (+116)
  • ATS Pick: Bengals +2.5 (-105)

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Saints vs Buccaneers

The Buccaneers have been frustratingly unreliable this season. They are also the worst division leader in the NFL at 5-6. The Bucs have lost four of their last six games and are coming off a loss to the Browns.

However, Tampa still has a top-10 defense despite not having anyone close to the top in the NFL DPOY odds. At home on a Monday night, that defense should be enough to earn a comfortable win.

Keep in mind the Saints have been dreadful offensively lately. New Orleans was shut out last week and has scored 13 points or less in three of the last four games. Defensively, the Saints should be able to keep themselves in this game.

But this New Orleans offense doesn’t look like a good bet to do much against the Tampa defense, helping get the Bucs back to .500 on the season.

  • SU Pick: Buccaneers (-186)
  • ATS Pick: Buccaneers -3.5 (-110)

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